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Dr Elisa Corsiero

Elisa

Senior Lecturer in Immunology

Centre: Experimental Medicine and Rheumatology

Email: e.corsiero@qmul.ac.uk
Telephone: +44(0) 20 7882 8193
X: @TheRealARGOsLab

Profile

ORCID iD: 0000-0003-2092-6778 

I am a Senior Lecturer at the Centre for Experimental Medicine & Rheumatology in the Immuno-Rheumatology group led by Prof Michele Bombardieri. I graduated from University of Milan (Italy) with an MSc in Industrial Biotechnology. In 2009, I joined the group of Prof Pitzalis and Prof Bombardieri in London for my PhD which I completed in 2013 with a thesis entitled: “Characterization of peripheral and lesional single B cell autoreactivity in patients with Sjögren’s syndrome and rheumatoid arthritis”. In 2014, I was awarded an Arthritis Research UK Foundation Fellowship which I completed in 2018. In November 2019, I was awarded with a competitive Career Development Fellowship from Versus Arthritis, which is funding my research. In 2022, I was awarded as PI a Large Project Grant from the Barts Charity on the generation of human antibodies specific to Sjögren’s Syndrome (SS) diseased tissue specific neoepitops for development of novel diagnostic and targeted immunotherapies.

Research

Group members

  • Post-doctoral Fellows: Dr Lucas Jagemann
  • PhD Students: Dr Mattia Caliste, Miss Mareike Werle
  • Visiting Research Fellows: Miss Nia Sciucca

Summary

My major research interests focus on the elucidation of the cellular and molecular mechanisms regulating autoreactive B cell activation, breach of self-tolerance and perpetuation of autoimmunity in Sjögren’s syndrome and rheumatoid arthritis. In particular, my research is focused on characterizing the fine specificity and function of monoclonal antibodies derived from single B cells and from antibody phage display technology in patients with rheumatic autoimmune diseases and cancer.

Point of contact for Biacore 1K+ SPR Instrument – Booking: iLab Centre for Experimental Medicine & Rheumatology.

Publications

  • (publicationYear). Novel fully human IgG1 targeting folate receptor α demonstrates antitumor efficacy driven by avidity rather than monovalent binding affinity. nameOfConference


  • Mancuso S, Caliste M, Petretto A et al. (2025). POS0199 ANTI-β2GLYCOPROTEIN I-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS CAUSE ENDOTHELIAL ACTIVATION. nameOfConference


    QMRO: qmroHref
  • Mancuso S, Caliste M, Petretto A et al. (2025). ANTI-Β2GLYCOPROTEIN I-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS CAUSE ENDOTHELIAL ACTIVATION. nameOfConference


    QMRO: qmroHref
  • (2025). Anti-β2glycoprotein I-induced neutrophil extracellular traps cause endothelial activation. nameOfConference


  • Caliste M, Prediletto E, Corsiero E et al. (2024). AB0784 STROMAL B-CELL CROSSTALK PROMOTES THE ESTABLISHMENT OF SYNOVIAL EBV+B-CELL NICHES THROUGH TYPE I INTERFERON SIGNALLING ACTIVATION. nameOfConference


  • Corsiero E, Caliste M, Pontarini E et al. (2024). POS0250 GENERATION AND VALIDATION OF A HUMAN IMMUNE scFv LIBRARY FROM SJÖGREN’S SYNDROME SALIVARY GLAND B-CELLS. nameOfConference


    QMRO: qmroHref
  • Mancuso S, Giacomassi C, Truglia S et al. (2023). POS1425 ANTIB2GLYCOPROTEIN I ANTIBODIES CAN INDUCE NETOSIS. nameOfConference


  • Carlotti E, Murray-Brown W, Blighe K et al. (2022). High-throughput sequencing of IgH gene in minor salivary glands from Sjögren's syndrome patients reveals dynamic B cell recirculation between ectopic lymphoid structures.. nameOfConference


  • Prediletto E, Cubuk C, Pontarini E et al. (2022). POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK. nameOfConference


  • Corsiero E, Caliste M, Jagemann L et al. (2022). POS0399 CHARACTERIZATION OF HSP60, A STROMAL-DERIVED AUTOANTIGEN, RECOGNIZED BY RA SYNOVIAL RECOMBINANT MONOCLONAL ANTIBODIES. nameOfConference


View profile publication page

Sponsors

Collaborators

Internal

External

  • Prof Paola Migliorini (Pisa University)
  • Dr Mariangela Figini (IRCSS Instituto Tumori, Milan)

Teaching

I am actively engaged in undergraduate teaching including: i) Module Lead of the BMD375 module and Lecturer for BMD171 of the BSc degree in Pharmacology & Innovative Therapeutics; ii) Tutor of BSc Pharmacology students; iii) PBL Facilitator.

Disclosures

No disclosures.

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